The Yeezy Boost 350 "Mono Clay" is one of three colorways that will launch a new silhouette structure in June 2021. The "Mono" line, which includes this "Clay" colorway as well as "Mist" and "Ice" variations, departs from the model's customary Primeknit woven upper in favor of a translucent monofilament mesh. A supporting "web" design sits beneath the mesh exterior. The "Mono Clay" colorway, like the original "Clay" Yeezy 350 from 2019, boasts an earthy hue of reddish-orange over the top. The heel pull button, laces, and transparent rubber sole continue the monochromatic Clay theme. The "Mono Clay" Yeezy 350 was only available in Asia, whereas the "Mono Ice" and "Mono Mist" colors were available in North America and Europe, respectively.

The upper of the Yeezy 350 V2 Mono Mist is made of monofilament mesh, a new material for the sneaker. Finally, a typical Boost sole has been put to the sole. The Yeezy 350 V2 Mono Mist was released in June of 2021 for $220, exclusively at AirBoostShoes.com